Beijing Hotgen Biotech Co.,Ltd.

Hotgen One-step Cardiac  Troponin I (cTnI) Test Cassette

Hotgen  One-step cTnI is a  rapid test used for the semi-quantitative determination of  cardiac troponin I (cTnI) in human serum, plasma and whole blood as an aiding  tool for early diagnosis of heart attack.

cTnI:  the most specific cardiac marker for AMI

Human  troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a  single isoform with molecular weight 23876 Da and it consists of 209 amino acid  residues.

For  more than 15 years cTnI has been known as a reliable marker of cardiac muscle  tissue injury. It is considered to be more sensitive and significantly more  specific in diagnosis of the myocardial infarction than Creatin Kinase isoenzyme  MM (CK-MB) and myoglobin.

Measurements  of cardiac troponin I are used in the diagnosis and treatment of myocardial  infarction and as an aid in the risk stratification of patients with acute  coronary syndromes with respect to their relative risk of  mortality.

For  optimal diagnostic usefulness, a cardiac marker should be specific for cardiac  tissue, should be rapidly released into the bloodstream with a direct  proportional relationship between the extent of myocardial injury and the  measured level of the marker, and should persist in blood for a sufficient  length of time to provide a convenient diagnostic time window. The  cardiac-specific troponins, troponin I (cTnI) and troponin T (cTnT) are  considered the biochemical markers of choice in the evaluation of acute coronary  syndromes (ACS) including ST-elevation myocardial infarction, non-ST-elevation  myocardial infarction, and unstable angina.

Elevated  levels of cardiac-specific troponins convey prognostic information beyond that  supplied by the patients clinical signs and symptoms, the ECG at presentation,  and the pre-discharge exercise test.

The  Joint European Society of Cardiology/American College of Cardiology Committee  (ESC/ACC) consensus guidelines for diagnosis of MI include observation of the  typical rise and fall of cardiac markers with at least one of: ischemic  symptoms, development of pathologic Q waves on electrocardiogram (ECG), ST  segment elevation or depression in ECG, or coronary artery intervention;  troponin is the preferred marker with a cutoff set at or above the 99th  percentile of the reference range.

The  World Health Organization (WHO) definition for diagnosis of MI requires the  presence of two of: unequivocal ECG changes, unequivocal cardiac marker changes,  prolonged chest pain.

Currently  it is widely practiced in the world that cTnI, CK-MB and myoglobin are  co-measured in suspicion of MI. However, more recently Heart-type Fatty  Acid-binding Protein (H-FABP) has emerged as a very specific and sensitive  cardiac biomarker for MI and the co-measurement of H-FABP and cTnI is on the  rise worldwide.

Hotgen One-Step  cTnI Kit Test  Principle

Colloidal  gold immunochromatographic method

Hotgen  One-step cTnI Test Features

Semi-quantitative  measurement

Rapid,  accurate, lab quality results within minutes

Ready-to-use  reagents

Serum,  plasma and whole blood are applicable as sample

Long  shelf life

Easy  storage at room temperature

Single  dose format: run only the test you need